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The key drawbacks to TLC are its minimal semi-quantitative details (when used with Visible detection) and the necessity for exact method (Kaale et al., 2011). TLC solvents are frequently harmful or flammable, so these substances may be challenging to transport for industry use. Furthermore, TLC supplies limited information regarding a drug's identification; two samples that vacation distinct distances are unquestionably not the identical substance, but two unique substances could surface identical applying any chromatography method Should they be chemically equivalent more than enough.

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